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1

Fractional kinetics in drug absorption and disposition processes

Aristides Dokoumetzidis, Panos Macheras

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2009

Language:

english

File:

PDF, 442 KB

english, 2009

2

Analysis of Dissolution Data Using Modified Versions of Noyes–Whitney Equation and the Weibull Function

Aristides Dokoumetzidis, Vasiliki Papadopoulou, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 400 KB

english, 2006

3

A method for robust model order reduction in pharmacokinetics

Aristides Dokoumetzidis, Leon Aarons

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2009

Language:

english

File:

PDF, 485 KB

english, 2009

4

Propagation of Population Pharmacokinetic Information Using a Bayesian Approach: Comparison with Meta-Analysis

Aristides Dokoumetzidis, Leon Aarons

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2005

Language:

english

File:

PDF, 332 KB

english, 2005

5

On the Heterogeneity of Drug Dissolution and Release

Panos Macheras, Aristides Dokoumetzidis

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 75 KB

english, 2000

6

Power law IVIVC: An application of fractional kinetics for drug release and absorption

John Kytariolos, Aristides Dokoumetzidis, Panos Macheras

Journal:

European Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 356 KB

english, 2010

7

On the ubiquitous presence of fractals and fractal concepts in pharmaceutical sciences: A review

Pippa, Natassa, Dokoumetzidis, Aristides, Demetzos, Costas, Macheras, Panos

Journal:

International Journal of Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

8

Population pharmacokinetic reanalysis of a Diazepam PBPK model: a comparison of Stan and GNU MCSim

Tsiros, Periklis, Bois, Frederic Y., Dokoumetzidis, Aristides, Tsiliki, Georgia, Sarimveis, Haralambos

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2019

Language:

english

File:

PDF, 1.85 MB

english, 2019

9

A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System

Aristides Dokoumetzidis, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

2006

Language:

english

File:

PDF, 367 KB

english, 2006

10

Biopharmaceutics classification systems for new molecular entities (BCS-NMEs) and marketed drugs (BCS-MD): Theoretical basis and practical examples

Vasiliki Papadopoulou, Georgia Valsami, Aristides Dokoumetzidis, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 485 KB

english, 2008

11

Application of optimal design methodologies in clinical pharmacology experiments

Kayode Ogungbenro, Aristides Dokoumetzidis, Leon Aarons

Journal:

Pharmaceutical Statistics

Year:

2009

Language:

english

File:

PDF, 236 KB

english, 2009

12

Propagation of Population PK and PD Information Using a Bayesian Approach: Dealing with Non-Exchangeability

Aristides Dokoumetzidis, Leon Aarons

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2006

Language:

english

File:

PDF, 251 KB

english, 2006

13

A Population Growth Model of Dissolution

Aristides Dokoumetzidis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

1997

File:

PDF, 447 KB

1997

14

Identification of Biowaivers Among Class II Drugs: Theoretical Justification and Practical Examples

Eleni Rinaki, Aristides Dokoumetzidis, Georgia Valsami, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2004

Language:

english

File:

PDF, 206 KB

english, 2004

15

Bayesian Optimal Designs for Pharmacokinetic Models: Sensitivity to Uncertainty

Dokoumetzidis, Aristides, Aarons, Leon

Journal:

Journal of Biopharmaceutical Statistics

Year:

2007

Language:

english

File:

PDF, 700 KB

english, 2007

16

IVIVC of controlled release formulations: Physiological–dynamical reasons for their failure

A. Dokoumetzidis, P. Macheras

Journal:

Journal of Controlled Release

Year:

2008

Language:

english

File:

PDF, 234 KB

english, 2008

17

Predictive models for oral drug absorption: from in silico methods to integrated dynamical models

Dokoumetzidis, Aristides, Kalantzi, Lida, Fotaki, Nikoletta

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2007

Language:

english

File:

PDF, 361 KB

english, 2007

18

Modelling and simulation in drug absorption processes

Dokoumetzidis, A., Valsami, G., Macheras, P.

Journal:

Year:

2007

Language:

english

File:

PDF, 258 KB

english, 2007

19

Serum and tissue pharmacokinetics of silibinin after per os and i.v. administration to mice as a HP-β-CD lyophilized product

Eirini, Christodoulou, Irene-Ariadne, Kechagia, Stavros, Tzimas, Evangelos, Balafas, Nikolaos, Kostomitsopoulos, Helen, Archontaki, Aristides, Dokoumetzidis, Georgia, Valsami

Journal:

International Journal of Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 1.15 MB

english, 2015

20

Hyperhydration Effect on Pharmacokinetic Parameters and Detection Sensitivity of Recombinant Human Erythropoietin in Urine and Serum Doping Control Analysis of Males

Athanasiadou, Ioanna, Dokoumetzidis, Aristeidis, Voss, Sven Christian, El Saftawy, Wesal, Al-Maadheed, Mohammed, Valsami, Georgia, Georgakopoulos, Costas

Journal:

Journal of Pharmaceutical Sciences

Year:

2019

Language:

english

File:

PDF, 1.55 MB

english, 2019

21

Development of a reaction-limited model of dissolution: Application to official dissolution tests experiments

A. Dokoumetzidis, V. Papadopoulou, G. Valsami, P. Macheras

Journal:

International Journal of Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 443 KB

english, 2008

22

Modeling of supersaturated dissolution data

Georgia Valsami, Aristides Dokoumetzidis, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

1999

Language:

english

File:

PDF, 92 KB

english, 1999

23

Nonlinear dynamics in Clinical Pharmacology: the paradigm of cortisol secretion and suppression

Aristides Dokoumetzidis, Athanassios Iliadis, Panos Macheras

Journal:

British Journal of Clinical Pharmacology

Year:

2002

Language:

english

File:

PDF, 216 KB

english, 2002

24

A commentary on fractionalization of multi-compartmental models

Aristides Dokoumetzidis, Richard Magin, Panos Macheras

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2010

Language:

english

File:

PDF, 220 KB

english, 2010

25

Fractional kinetics in multi-compartmental systems

Aristides Dokoumetzidis, Richard Magin, Panos Macheras

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2010

Language:

english

File:

PDF, 735 KB

english, 2010

26

The Changing Face of the Rate Concept in Biopharmaceutical Sciences: From Classical to Fractal and Finally to Fractional

Aristides Dokoumetzidis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 154 KB

english, 2011

27

Modeling and Monte Carlo Simulations in Oral Drug Absorption

Aristides Dokoumetzidis, Kosmas Kosmidis, Panos Argyrakis, Panos Macheras

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2005

Language:

english

File:

PDF, 182 KB

english, 2005

28

Biopharmaceutical Classification Based on Solubility and Dissolution: A Reappraisal of Criteria for Hypothesis Models in the Light of the Experimental Observations

Georgia Charkoftaki, Aristides Dokoumetzidis, Georgia Valsami, Panos Macheras

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2010

Language:

english

File:

PDF, 134 KB

english, 2010

29

An alternative method for the estimation of the terminal slope when a few data points are available

Aristides Dokoumetzidis, Athanassios Iliadis, Panos Macheras

Journal:

Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 62 KB

english, 1999

30

Nonlinear Dynamics and Chaos Theory: Concepts and Applications Relevant to Pharmacodynamics

Aristides Dokoumetzidis, Athanassios Iliadis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 464 KB

english, 2001

31

Investigation of Absorption Kinetics by the Phase Plane Method

Aristides Dokoumetzidis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 568 KB

1998

32

The Homoclinic Tangle of A 1:2 Resonance in a 2-D Hamiltonian System

C. Polymilis, G. Contopoulos, A. Dokoumetzidis

Journal:

Celestial Mechanics and Dynamical Astronomy

Year:

2003

Language:

english

File:

PDF, 677 KB

english, 2003

33

The Mean Dissolution Time Depends on the Dose/Solubility Ratio

Eleni Rinaki, Aristides Dokoumetzidis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2003

Language:

english

File:

PDF, 68 KB

english, 2003

34

Monte Carlo simulations and fractional kinetics considerations for the Higuchi equation

Aristides Dokoumetzidis, Kosmas Kosmidis, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

2011

Language:

english

File:

PDF, 435 KB

english, 2011

35

On the use of partial AUC as an early exposure metric

Aristides Dokoumetzidis, Panos Macheras

Journal:

European Journal of Pharmaceutical Sciences

Year:

2000

Language:

english

File:

PDF, 272 KB

english, 2000

36

Proper lumping in systems biology models

Dokoumetzidis, A., Aarons, L.

Journal:

IET Systems Biology

Year:

2009

Language:

english

File:

PDF, 529 KB

english, 2009

37

Elucidating the Role of Dose in the Biopharmaceutics Classification of Drugs: The Concepts of Critical Dose, EffectiveIn VivoSolubility, and Dose-Dependent BCS

Georgia Charkoftaki, Aristides Dokoumetzidis, Georgia Valsami, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2012

Language:

english

File:

PDF, 600 KB

english, 2012

38

The heterogeneous course of drug transit through the body

Aristides Dokoumetzidis, Vangelis Karalis, Athanassios Iliadis, Panos Macheras

Journal:

Trends in Pharmacological Sciences

Year:

2004

Language:

english

File:

PDF, 668 KB

english, 2004

39

Supersaturated dissolution data and their interpretation: the TPGS–carbamazepine model case

Georgia Charkoftaki, Aristides Dokoumetzidis, Georgia Valsami, Panos Macheras

Journal:

Journal of Pharmacy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 390 KB

english, 2011

40

A Model for Transport and Dispersion in the Circulatory System Based on the Vascular Fractal Tree

Aristides Dokoumetzidis, Panos Macheras

Journal:

Annals of Biomedical Engineering

Year:

2003

Language:

english

File:

PDF, 273 KB

english, 2003

41

The interplay between the rate of release from polymer grafted liposomes and their fractal morphology

Pippa, Natassa, Dokoumetzidis, Aristides, Pispas, Stergios, Demetzos, Costas

Journal:

International Journal of Pharmaceutics

Year:

2014

Language:

english

File:

PDF, 1.32 MB

english, 2014

42

Author index

Pippa, Natassa, Dokoumetzidis, Aristides, Demetzos, Costas, Macheras, Panos

Journal:

Regulatory Peptides

Year:

1982

Language:

english

File:

PDF, 162 KB

english, 1982

43

Analytical Expressions for Combining Population Pharmacokinetic Parameters from Different Studies

Dokoumetzidis, Aristides, Aarons, Leon

Journal:

Journal of Biopharmaceutical Statistics

Year:

2008

Language:

english

File:

PDF, 402 KB

english, 2008

44

Pharmacokinetics of doripenem in CSF of patients with non-inflamed meninges

Nalda-Molina, R., Dokoumetzidis, A., Charkoftaki, G., Dimaraki, E., Margetis, K., Archontaki, H., Markantonis, S., Boutos, N., Sakas, D., Vryonis, E., Skoutelis, A., Valsami, G.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2012

Language:

english

File:

PDF, 366 KB

english, 2012

45

Development of a paediatric population pharmacokinetic model for valacyclovir from literature non-compartmental values originating from sparse studies and Bayesian priors: a simulation study

Kechagia, Irene-Ariadne, Dokoumetzidis, Aristides

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2015

Language:

english

File:

PDF, 751 KB

english, 2015

46

A bioassay for determining voriconazole serum levels in patients receiving combination therapy with echinocandins

Siopi, Maria, Neroutsos, Efthymios, Zisaki, Kalliopi, Gamaletsou, Maria, Piroynaki, Maria, Tsirigotis, Panagiotis, Sipsas, Nikolaos, Dokoumetzidis, Aristides, Goussetis, Evgenios, Zerva, Loukia, Valsa

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 546 KB

english, 2015

47

A Comment on “Adverse Drug Reactions and Avalanches: Life at the Edge of Chaos”

Dokoumetzidis, Aristides, Macheras, Panos

Journal:

Journal of Clinical Pharmacology

Year:

2006

Language:

english

File:

PDF, 144 KB

english, 2006

48

Extrapolation of enalapril efficacy from adults to children using pharmacokinetic/pharmacodynamic modelling

Kechagia, Irene-Ariadne, Kalantzi, Lida, Dokoumetzidis, Aristides

Journal:

Journal of Pharmacy and Pharmacology

Year:

2015

Language:

english

File:

PDF, 664 KB

english, 2015

49

Extrapolation of Valacyclovir Posology to Children Based on Pharmacokinetic Modeling

Kechagia, Irene Ariadne, Kalantzi, Lida, Dokoumetzidis, Aristides

Journal:

Pediatric Infectious Disease Journal

Year:

2015

Language:

english

File:

PDF, 319 KB

english, 2015

50

Fractional calculus in pharmacokinetics

Sopasakis, Pantelis, Sarimveis, Haralambos, Macheras, Panos, Dokoumetzidis, Aristides

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2017

Language:

english

File:

PDF, 861 KB

english, 2017